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clear Methadone

Why is this medication prescribed?

Methadone is used to relieve moderate to severe pain that has not been relieved by non-narcotic pain relievers. It also is used to prevent withdrawal symptoms in patients who were addicted to opiate drugs and are enrolled in treatment programs in order to stop taking or continue not taking the drugs. Methadone is in a class of medications called opiate (narcotic) analgesics. Methadone works to treat pain by changing the way the brain and nervous system respond to pain. It also works as a substitute for opiate drugs of abuse by producing similar effects and preventing withdrawal symptoms in people who have stopped using these drugs.

Important Warning

Methadone may cause slowed breathing and irregular heartbeat which may be life-threatening. If you experience any of the following symptoms, call your doctor immediately: difficulty breathing; extreme drowsiness; slow, shallow breathing; fast, slow, pounding or irregular heartbeat; faintness; severe dizziness; or confusion.

The risk that you will experience serious or life-threatening side effects of methadone is greatest when you first start taking methadone, when you switch from another narcotic medication to methadone and when your doctor increases your dose of methadone. Your doctor may start you on a low dose of methadone and gradually increase your dose. Your doctor will monitor you closely during this time.

Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take methadone exactly as directed. Do not take more methadone or take methadone more often than prescribed by your doctor. If you are taking methadone to control pain, your pain may return before it is time for your next dose of methadone. If this happens, do not take an extra dose of methadone. You will still have methadone in your body after the pain relieving effect of the medication wears off. If you take extra doses, you may have too much methadone in your body and you may experience life-threatening side effects. Be aware that the pain relieving effects of methadone will last longer as your treatment continues for a longer time. Talk to your doctor if your pain is not controlled during your treatment with methadone.

Talk to your doctor about the risks of taking methadone for your condition.

Use of methadone to treat opiate addiction:

If you have been addicted to an opiate (narcotic drug such as heroin), and you are taking methadone to help you stop taking or continue not taking the drug, you must enroll in a treatment program. The treatment program must be approved by the state and federal governments and must treat patients according to specific federal laws. You may have to take your medication at the treatment program facility under the supervision of the program staff. Ask your doctor or the treatment program staff if you have any questions about enrolling in the program or taking or getting your medication.

How should this medicine be used?

Methadone comes as a tablet, a dispersible tablet (can be dissolved in liquid), a solution (liquid), and a concentrated solution (liquid that must be diluted before use) to take by mouth. When methadone is used to relieve pain, it may be taken every 4 to 12 hours. If you take methadone as part of a treatment program, your doctor will prescribe the dosing schedule that is best for you.

Your doctor may change your dose of methadone during your treatment. Your doctor may decrease your dose or tell you to take methadone less often as your treatment continues. Ask your doctor or pharmacist if you have any questions about how much methadone you should take or how often you should take the medication.

Methadone can be habit-forming. Call your doctor if you find that you want to take extra medication or notice any other unusual changes in your behavior or mood.

Do not stop taking methadone without talking to your doctor. Your doctor will probably want to decrease your dose gradually. If you suddenly stop taking methadone, you may experience withdrawal symptoms such as restlessness, teary eyes, runny nose, yawning, sweating, chills, muscle pain, and widened pupils (black circles in the middle of the eyes).

If you are using the dispersible tablets, place one tablet in a liquid such as water or citrus fruit juice. Wait 1 minute to allow the tablet to dissolve and then drink the entire mixture.

If you are using methadone oral concentrate solution, you should mix your prescribed dose of medication in at least 1 ounce of liquid such as water, citrus fruit juice, Kool Aid®, Tang®, apple juice, or Crystal Light®.

What side effects can this medication cause?

Methadone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • drowsiness
  • weakness
  • headache
  • nausea
  • vomiting
  • constipation
  • loss of appetite
  • weight gain
  • stomach pain
  • dry mouth
  • sweating
  • flushing
  • difficulty urinating
  • swelling of the hands, arms, feet, and legs
  • mood changes
  • vision problems
  • difficulty falling asleep or staying asleep
  • decreased sexual desire or ability
  • missed menstrual periods
Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately:
  • seizures
  • itching
  • hives
  • rash
Methadone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.


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